RNaseZap™ RNase Decontamination Solution is a surface decontamination solution that destroys RNases on contact. Simply spray RNaseZap™ Solution onto the surface to be decontaminated and then rinse off with RNase-free water.

RNaseZap™ RNase Decontamination Solution Features:

• Completely removes RNase contamination from glass and plastic surfaces
• Excellent at removing high levels of RNase contamination that comparable products struggle with
• Proven effective at removing high concentrations of dried RNase A
• Ideal for cleaning benchtops, pipettes, and equipment that must be RNase-free

Using RNaseZap™ Solution
Working with RNA requires special measures to ensure an RNase-free environment. Even trace amounts of RNase can lead to reduced yields from in vitro transcription reactions, degradation during RNA purification protocols, and variability in RPA and Northern results. RNaseZap™ contains three RNase-resistant active ingredients that have been shown to be very effective in removing RNase contamination from glassware, plastic surfaces, countertops, and pipettes. It has also been shown to be effective in removing RNase contamination from microcentrifuge tubes without inhibiting subsequent enzymatic reactions. Supplied in single-serving 250 mL bottles.

RNase Contamination in Microcentrifuge Tubes
While RNase contamination of frequently handled labware is a common and legitimate concern, researchers often do not worry about RNase contamination of commercially prepared products such as microcentrifuge tubes. However, in a survey of six standard 1.5 mL microcentrifuge tubes (three tubes pre-rinsed with RNaseZap™ and water and three tubes left untreated), all of the untreated tubes had at least borderline levels of RNase contamination, while none of the tubes pre-rinsed with RNaseZap™ had contamination. In addition, approximately 10% of commercially available “RNase-free” microcentrifuge tubes tested had some level of RNase contamination (data not shown). This could explain why researchers occasionally get erratic results when performing RNA-based assays.